Intoxicated with Raison d’etat

The raison d'être of chemical ecology.

Chemical ecology is a mechanistic approach to understanding the causes and consequences of species interactions, distribution, abundance, and diversity. The promise of chemical ecology stems from its potential to provide causal mechanisms that further our understanding of ecological interactions and allow us to more effectively manipulate managed systems. Founded on the notion that all organism...

Spreading the practice of evidence-based medicine: MetaStar's raison d'etre.

On cytoadhesion of Plasmodium vivax: raison d'être?

It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to...

A sertraline-intoxicated driver.

Sertraline is a selective serotonin reuptake inhibitor (SSRI) that is chemically unrelated to other SSRIs, tricyclic antidepressants, and other currently available antidepressant medications. This report documents a case of driving under the influence of sertraline. The subject was involved in a motor vehicle accident. Upon contact by law enforcement, the subject was confused and could neither ...

The intoxicated EEG

A 38-year old male patient with pharmacoresistant bilateral temporal-lobe epilepsy was referred to our department for adjustment of antiepileptic-drug dosage with continuous VideoEEG monitoring. In 2013, bilateral deep brain electrodes were implanted for chronic stimulation in both anterior thalamic nuclei. After implantation, the patient remained seizure free of generalized tonic-clonic seizur...